Wissenschaftliche Publikationen
Forschungserfahrung als Grundlage meiner Beratung
Als promovierter Naturwissenschaftler verfüge ich über langjährige Erfahrung in der molekularbiologischen und biomedizinischen Forschung. Meine wissenschaftliche Tätigkeit umfasst unter anderem Arbeiten zur zellulären Signaltransduktion, Herz-Kreislauf-Physiologie, Pharmakologie sowie molekularen und zellbiologischen Mechanismen.
Die folgenden wissenschaftlichen Publikationen dokumentieren einen Teil meiner Forschungsarbeit.
Wissenschaftliche Publikationen
2026
Pluteanu F, Heinick A, Domnik-Lehnert M, Müller FU, Hermes C.
Annexin A4 Deficient Ventricular Myocytes Display Advanced Hypertrophy and Electrical Remodeling With Chronic β-Adrenoceptor Stimulation.
The FASEB Journal 40(17): e72213.
2023
Herting JR, König JH, Hadova K, Heinick A, Müller FU, Pauls P, Seidl MD, Soppa C, Kirchhefer U.
Hypercontractile cardiac phenotype in mice overexpressing the regulatory subunit PR72 of protein phosphatase 2A.
Frontiers in Cardiovascular Medicine 10:1239555.
DOI: 10.3389/fcvm.2023.1239555
Herting JR, Berg AM, Hadova K, Heinick A, König S, Kuhlmann M, Müller FU, Kirchhefer U.
Myocardial overexpression of protein phosphatase 2A-B56α improves resistance against ischemia-reperfusion injury.
Journal of Molecular and Cellular Cardiology Plus 3:100030.
DOI: 10.1016/j.jmccpl.2022.100030
2022
Glaser D, Heinick A, Herting JR, Massing F, Müller FU, Pauls P, Rozhdestvensky TS, Schulte JS, Seidl MD, Skryabin BV, Stümpel F, Kirchhefer U.
Impaired myocellular Ca²⁺ cycling in protein phosphatase PP2A-B56α knockout mice is normalized by β-adrenergic stimulation.
Journal of Biological Chemistry 298(9):102362.
DOI: 10.1016/j.jbc.2022.102362
Pluteanu F, Boknik P, Heinick A, König C, Müller FU, Weidlich A, Kirchhefer U.
Activation of PKC results in improved contractile effects and Ca²⁺ cycling by inhibition of PP2A-B56α.
American Journal of Physiology – Heart and Circulatory Physiology 322(3):H427–H441.
DOI: 10.1152/ajpheart.00539.2021
2020
Heinick A, Pluteanu F, Hermes C, Klemme A, Domnik M, Husser X, Gerke V, Schmitz W, Müller FU.
Annexin A4 N-terminal peptide inhibits adenylyl cyclase 5 and limits β-adrenoceptor-mediated prolongation of cardiac action potential.
The FASEB Journal 34(8):10489–10504.
Seidl MD, Fels B, Kranick D, Sternberg A, Grimm K, Stümpel FT, Pluteanu F, Schulte JS, Heinick A, Kojima N, Endo S, Huge A, Stoll M, Müller FU.
Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic β-adrenergic stimulation.
The FASEB Journal 34(8):11272–11291.
2018
Kirchhefer U, Hammer E, Heinick A, Herpertz T, Isensee G, Müller FU, Neumann J, Schulte K, Seidl MD, Boknik P, Schulte JS.
Chronic β-adrenergic stimulation reverses depressed Ca handling in mice overexpressing inhibitor-2 of protein phosphatase 1.
Journal of Molecular and Cellular Cardiology 125:195–204.
DOI: 10.1016/j.yjmcc.2018.10.022
2016
Schulte JS, Fehrmann E, Tekook MA, Kranick D, Fels B, Li N, Wehrens XHT, Heinick A, Seidl MD, Schmitz W, Müller FU.
Cardiac expression of the CREM repressor isoform CREMΔC-IbΔC-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes.
Basic Research in Cardiology 111:15.
DOI: 10.1007/s00395-016-0532-y
2015
Heinick A, Husser X, Himmler K, Kirchhefer U, Nunes F, Schulte JS, Seidl MD, Rolfes C, Dedman JR, Kaetzel MA, Gerke V, Schmitz W, Müller FU.
Annexin A4 is a novel direct regulator of adenylyl cyclase type 5.
The FASEB Journal 29(9):3773–3787.
DOI: 10.1096/fj.14-269837
Zhang M, Schulte JS, Heinick A, Piccini I, Rao J, Quaranta R, Zeuschner D, Malan D, Kim KP, Röpke A, Sasse P, Araúzo-Bravo M, Seebohm G, Schöler H, Fabritz L, Kirchhof P, Müller FU, Greber B.
Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation.
Stem Cells 33(5):1456–1469.
DOI: 10.1002/stem.1964
2014
Kirchhefer U, Heinick A, König S, Kristensen T, Müller FU, Seidl MD, Boknik P.
Protein phosphatase 2A is regulated by protein kinase Cα (PKCα)-dependent phosphorylation of its targeting subunit B56α at Ser41.
Journal of Biological Chemistry 289(1):163–176.
2013
Stegemann A, Sindrilaru A, Eckes B, del Rey A, Heinick A, Schulte JS, Müller FU, Grando SA, Fiebich BL, Scharffetter-Kochanek K, Luger TA, Böhm M.
Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model.
Arthritis & Rheumatism 65(3):792–804.
DOI: 10.1002/art.37809
2012
Kučerová D, Baba HA, Bokník P, Fabritz L, Heinick A, Mát'uš M, Müller FU, Neumann J, Schmitz W, Kirchhefer U.
Modulation of SR Ca²⁺ release by the triadin-to-calsequestrin ratio in ventricular myocytes.
American Journal of Physiology – Heart and Circulatory Physiology 302(10):H2008–H2017.
DOI: 10.1152/ajpheart.00457.2011
2010
Heinick A, Urban K, Roth S, Spies D, Nunes F, Phanstiel IV O, Liebau E, Lüersen K.
Caenorhabditis elegans P5B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA interference.
The FASEB Journal 24(1):206–217.
DOI: 10.1096/fj.09-135889
Freyth K, Janowitz T, Nunes F, Voss M, Heinick A, Bertaux J, Scheu S, Paul RJ.
Reproductive fitness and dietary choice behavior of the genetic model organism Caenorhabditis elegans under semi-natural conditions.
Molecules and Cells 30(4):347–353.
DOI: 10.1007/s10059-010-0125-9
2008
Burmeister C, Lüersen K, Heinick A, Hussein A, Domagalski M, Walter RD, Liebau E.
Oxidative stress in Caenorhabditis elegans: protective effects of the Omega class glutathione transferase (GSTO-1).
The FASEB Journal 22(2):343–354.
Wolf M, Nunes F, Henkel A, Heinick A, Paul RJ.
The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness.
Journal of Cellular Physiology 214(3):721–729.
DOI: 10.1002/jcp.21269